Discovery of chemical reactions through multidimensional screening

J Am Chem Soc. 2007 Feb 7;129(5):1413-9. doi: 10.1021/ja0674744.

Abstract

Multidimensional reaction screening of ortho-alkynyl benzaldehydes with a variety of catalysts and reaction partners was conducted in an effort to identify new chemical reactions. Reactions affording unique products were selected for investigation of preliminary scope and limitations.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alkynes / chemistry*
  • Benzaldehydes / chemistry*
  • Biological Products / chemistry
  • Catalysis
  • Combinatorial Chemistry Techniques*
  • Drug Evaluation, Preclinical / methods*
  • Ligands
  • Models, Chemical
  • Phenols / chemistry

Substances

  • Alkynes
  • Benzaldehydes
  • Biological Products
  • Ligands
  • Phenols