Abstract
We report herein a simple, scalable, transition-metal-free approach to the synthesis of alpha-aryl methyl ketones from diazonium tetrafluoroborate salts under mild conditions. This methodology uses easily accessible and nontoxic starting material and was applied to the multi-kilogram-scale preparation of 1-(3-bromo-4-methylphenyl)propan-2-one.
MeSH terms
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Catalysis
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Chromatography, High Pressure Liquid
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Hydrocarbons, Brominated / chemical synthesis
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Ketones / chemistry*
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Magnetic Resonance Spectroscopy
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Metals / chemistry
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Propane / analogs & derivatives
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Propane / chemical synthesis
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Solvents
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Spectrometry, Mass, Electrospray Ionization
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Transition Elements / chemistry*
Substances
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1-(3-bromo-4-methylphenyl)propan-2-one
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Hydrocarbons, Brominated
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Ketones
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Metals
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Solvents
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Transition Elements
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Propane