Abstract
Chemiluminescence experiments demonstrate that simple nitroalkenes release low levels of nitric oxide. UV and EPR measurements suggest but cannot confirm direct NO release from nitroalkenes. Given the biological activity of nitrated unsaturated fatty acids, these results suggest the possible metabolic conversion of nitroalkenes to NO.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Alkenes / chemical synthesis*
-
Alkenes / chemistry*
-
Chemistry, Pharmaceutical / methods*
-
Dose-Response Relationship, Drug
-
Drug Design
-
Electron Spin Resonance Spectroscopy
-
Luminescence
-
Models, Chemical
-
Molecular Conformation
-
Nitric Oxide / chemistry
-
Nitric Oxide Donors
-
Nitro Compounds / chemistry
-
Spectrophotometry, Ultraviolet
-
Time Factors
Substances
-
Alkenes
-
Nitric Oxide Donors
-
Nitro Compounds
-
Nitric Oxide