Cell-based biosensors for single cell monitoring and drug analysis

Ping Wang; Gaixia Xu; Lifeng Qin; Ying Xu; Yan Li

doi:10.1109/IEMBS.2004.1403576

Cell-based biosensors for single cell monitoring and drug analysis

Conf Proc IEEE Eng Med Biol Soc. 2004:2004:1949-52. doi: 10.1109/IEMBS.2004.1403576.

Authors

Ping Wang¹, Gaixia Xu, Lifeng Qin, Ying Xu, Yan Li

Affiliation

¹ Department of Biomedical Engineering, Zhejiang University, Hangzhou, China. [email protected]

PMID: 17272096
DOI: 10.1109/IEMBS.2004.1403576

Abstract

Cell-based biosensors incorporate cells as sensing elements that convert a change in immediate environment to signals conducive for processing. It characterizes with high sensitivity, excellent selectivity and fast response. Cell-based biosensors have been implemented for a number of applications ranging from pharmaceutical screening to environmental pollutant detection. This work demonstrate a novel cell-based biosensor following the principle of light-addressable potentiometric sensor and field effect transistor for detecting the action potential of single living cell under drugs. The experimental results agree with our expectation.