Abstract
A 32-year-old woman was treated with long-term voriconazole therapy for recurrent aspergillosis associated with chronic granulomatous disease. A short time after commencement of voriconazole therapy, a severe photosensitivity reaction developed. Continued voriconazole exposure led to the development of multifocal facial squamous cell carcinomas. The photosensitivity reaction resolved after the patient changed therapy to posaconazole.
MeSH terms
-
Adult
-
Antifungal Agents / adverse effects*
-
Antifungal Agents / therapeutic use
-
Carcinoma, Squamous Cell / etiology*
-
Female
-
Granulomatous Disease, Chronic / drug therapy
-
Humans
-
Photosensitivity Disorders / chemically induced*
-
Photosensitivity Disorders / diagnosis
-
Photosensitivity Disorders / pathology
-
Pyrimidines / adverse effects*
-
Pyrimidines / therapeutic use
-
Skin Neoplasms / etiology*
-
Triazoles / adverse effects*
-
Triazoles / therapeutic use
-
Voriconazole
Substances
-
Antifungal Agents
-
Pyrimidines
-
Triazoles
-
Voriconazole