Abstract
The occurrence of post-transplant lymphoproliferative disorders (PTLDs) after allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents a clinical problem. Pretransplant Epstein-Barr virus serological status and viral load was determined in 21 recipients and 28 control transplanted patients, with (+) and without (-) PTLD, respectively. Early-antigen immunoglobulin G (EA-IgG) was detected in 12/21 PTLD+ patients, but only 2/28 PTLD patients (P = 0.00023, Odds ratio = 17.42). High viral load was detected in peripheral blood mononuclear cells at PTLD diagnosis, independently of deleted LMP1. Detection of EA-IgG in allo-HSCT recipients pretransplantation might be considered as risk factor for PTLD development.
MeSH terms
-
Adolescent
-
Adult
-
Anemia, Aplastic / surgery
-
Anemia, Aplastic / virology
-
Antibodies, Viral / blood*
-
Antigens, Viral / immunology*
-
Biomarkers / blood
-
Case-Control Studies
-
Cell Count
-
Child
-
Child, Preschool
-
Epstein-Barr Virus Infections / diagnosis*
-
Fanconi Anemia / surgery
-
Fanconi Anemia / virology
-
Female
-
Flow Cytometry
-
Hematopoietic Stem Cell Transplantation*
-
Herpesvirus 4, Human*
-
Humans
-
Leukemia / surgery
-
Leukemia / virology
-
Lymphoproliferative Disorders / etiology*
-
Lymphoproliferative Disorders / virology
-
Male
-
Middle Aged
-
Multiple Myeloma / surgery
-
Multiple Myeloma / virology
-
Odds Ratio
-
Prognosis
-
Retrospective Studies
-
Risk Factors
-
Serologic Tests
-
Transplantation, Homologous
-
Viral Load
Substances
-
Antibodies, Viral
-
Antigens, Viral
-
Biomarkers
-
Epstein-Barr virus early antigen