Abstract
While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.
MeSH terms
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HSP90 Heat-Shock Proteins / antagonists & inhibitors
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Hydroxybenzoates / chemistry*
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Lactones / chemical synthesis*
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Lactones / chemistry
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Lactones / pharmacology
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Macrocyclic Compounds / chemical synthesis
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Macrocyclic Compounds / chemistry
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Macrocyclic Compounds / pharmacology
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Macrolides / chemical synthesis
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Macrolides / chemistry
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Macrolides / pharmacology
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Mitogen-Activated Protein Kinases / antagonists & inhibitors
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Molecular Structure
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Mycotoxins / chemical synthesis*
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Mycotoxins / chemistry
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Mycotoxins / pharmacology
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Zearalenone / analogs & derivatives
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Zearalenone / chemical synthesis
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Zearalenone / chemistry
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Zearalenone / pharmacology
Substances
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HSP90 Heat-Shock Proteins
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Hydroxybenzoates
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LL Z1640-2
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Lactones
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Macrocyclic Compounds
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Macrolides
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Mycotoxins
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hypothemycin
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Zearalenone
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Mitogen-Activated Protein Kinases
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monorden
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beta-resorcylic acid