Comparative Quantification of Contractile Force of Cardiac Muscle Using a Micro-mechanical Cell Force Measurement System

Seokchang Ryu; Byungkyu Kim; Deokho Kim; Sukho Park

doi:10.1109/IEMBS.2005.1615618

Comparative Quantification of Contractile Force of Cardiac Muscle Using a Micro-mechanical Cell Force Measurement System

Conf Proc IEEE Eng Med Biol Soc. 2005:2005:5077-80. doi: 10.1109/IEMBS.2005.1615618.

Authors

Seokchang Ryu¹, Byungkyu Kim, Deokho Kim, Sukho Park

Affiliation

¹ Korea Institute of Science and Technology, Seoul, Korea and Seoul National University, Seoul, Korea (e-mail: [email protected]).

PMID: 17281388
DOI: 10.1109/IEMBS.2005.1615618

Abstract

In order to develop the cell based robot, we presented a micro-mechanical force measurement system for the biological muscle actuators, which utilize glucose as a power source for potential application in digestive organ. The proposed system is composed of a micro-manipulator, a force transducer with a glass probe, a signal processor, an inverted microscope and video recoding system. Using this measurement system, the contractile force and frequency of the cardiac myocytes were measured in real time and the magnitudes of the contractile force of each cardiac myocyte under different conditions were compared. From the quantitative experimental results, we could estimate that the force of cardiac myocytes is about 20~40 N, and show that there is difference between the control cells and the micro-patterned cells.