Abstract
Central mechanisms of neuropathy induced by chronic ethanol treatment are almost unknown. In this study, rats were treated with ethanol-diet for 72 days. Mechanical hyperalgesia was observed during ethanol consumption, even after ethanol withdrawal. Under these conditions, a microglial marker ionized calcium-binding adaptor molecule 1-, but not a neuron marker microtuble associated protein-2-, like immunoreactivies were increased in the rat spinal cord. Furthermore, hypertrophy of microglia was clearly observed following chronic ethanol consumption. These findings support the idea that the activation and hypertrophy of microglia in the spinal cord may be, at least in part, associated with in the induction of ethanol-dependent neuropathic pain-like state.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Afferent Pathways / drug effects
-
Afferent Pathways / pathology
-
Afferent Pathways / physiopathology
-
Alcoholic Neuropathy / metabolism
-
Alcoholic Neuropathy / pathology
-
Alcoholic Neuropathy / physiopathology*
-
Animals
-
Biomarkers / analysis
-
Biomarkers / metabolism
-
Calcium-Binding Proteins / drug effects
-
Calcium-Binding Proteins / metabolism
-
Central Nervous System Depressants / adverse effects
-
Ethanol / adverse effects
-
Hyperalgesia / chemically induced
-
Hyperalgesia / pathology
-
Hyperalgesia / physiopathology
-
Hypertrophy / chemically induced
-
Hypertrophy / pathology
-
Hypertrophy / physiopathology
-
Male
-
Microfilament Proteins
-
Microglia / drug effects*
-
Microglia / pathology
-
Neurons, Afferent / drug effects
-
Neurons, Afferent / metabolism
-
Neurons, Afferent / pathology
-
Pain Measurement / drug effects
-
Pain Threshold / drug effects
-
Pain Threshold / physiology
-
Peripheral Nerves / drug effects
-
Peripheral Nerves / pathology
-
Peripheral Nerves / physiopathology
-
Rats
-
Rats, Inbred F344
-
Spinal Cord / drug effects*
-
Spinal Cord / pathology
-
Spinal Cord / physiopathology*
-
Up-Regulation / drug effects
-
Up-Regulation / physiology
Substances
-
Aif1 protein, rat
-
Biomarkers
-
Calcium-Binding Proteins
-
Central Nervous System Depressants
-
Microfilament Proteins
-
Ethanol