Abstract
We aimed to study, retrospectively, the neonatal outcome of 45 preterm neonates with intraventricular hemorrhage (IVH) who were delivered vaginally with intravenous meperidine (n = 23) or epidural analgesia (n = 22). Neonates in the epidural group had a better outcome in terms of a first-minute Apgar score of 7 or less, in 31% vs 69% (P = 0.001); 5-min Apgar score of 7 or less, in 18% vs 82% (P = 0.003); a lower incidence of respiratory distress syndrome (RDS; 23% vs 30%; P = 0.03); a lower dopamine requirement during the first neonatal week (13% vs 72%; P = 0.01); and a higher survival rate (91% vs 58%, respectively; P = 0.008). It is concluded that preterm neonates with IVH had a better outcome when delivered to mothers receiving epidural analgesia as compared to those receiving intravenous meperidine.
MeSH terms
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Adult
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Analgesia, Epidural / adverse effects*
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Analgesia, Epidural / methods
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Analgesics, Opioid / administration & dosage
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Analgesics, Opioid / adverse effects
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Anesthesia, Intravenous / adverse effects*
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Anesthesia, Intravenous / methods
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Anesthesia, Obstetrical / adverse effects*
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Anesthesia, Obstetrical / methods
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Anesthetics, Local / administration & dosage
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Anesthetics, Local / adverse effects
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Apgar Score
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Bupivacaine / administration & dosage
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Bupivacaine / adverse effects
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Cerebral Hemorrhage / epidemiology*
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Cerebral Ventricles
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Comorbidity
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Dopamine / administration & dosage
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Dopamine Agents / administration & dosage
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Female
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Humans
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Incidence
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Infant, Newborn
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Infant, Premature*
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Meperidine / administration & dosage
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Meperidine / adverse effects*
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Mothers
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Pregnancy
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Respiratory Distress Syndrome, Newborn / epidemiology
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Retrospective Studies
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Risk Factors
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Survival Rate
Substances
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Analgesics, Opioid
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Anesthetics, Local
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Dopamine Agents
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Meperidine
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Dopamine
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Bupivacaine