[Study on polymorphisms in metabolic enzyme genes, DNA repair genes and individual susceptibility to hepatocellular carcinoma]

Xin-ping Ye; Tao Peng; Le-qun Li

[Study on polymorphisms in metabolic enzyme genes, DNA repair genes and individual susceptibility to hepatocellular carcinoma]

Wei Sheng Yan Jiu. 2006 Nov;35(6):805-7.

[Article in Chinese]

Authors

Xin-ping Ye¹, Tao Peng, Le-qun Li

Affiliation

¹ Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

PMID: 17290773

Abstract

Hepatocellualr carcinoma is one of the most malignancy, and the pathogenesis has not been clarified yet. The individual variation in the capacity of xenobiotic metabolizing and DNA repair was the genetic susceptibility to malignancies. Studies on polymorphisms of metabolic enzymes (CYP, NAT, GST, EH, ALDH) and DNA repair genes (XRCC1,hOGG1,XPD), and susceptibility to hepatocellular carcinoma are reviewed in this paper.

Publication types

English Abstract
Research Support, Non-U.S. Gov't
Review

MeSH terms

Carcinoma, Hepatocellular / genetics*
Cytochrome P-450 Enzyme System / genetics*
DNA Repair / genetics*
Genetic Predisposition to Disease
Glutathione Transferase / genetics
Humans
Liver Neoplasms / genetics*
Peroxidase / genetics
Polymorphism, Genetic

Substances

Cytochrome P-450 Enzyme System
Peroxidase
Glutathione Transferase