Functional results after radiochemotherapy and total mesorectal excision for rectal cancer

Int J Colorectal Dis. 2007 Aug;22(8):903-10. doi: 10.1007/s00384-007-0276-0. Epub 2007 Feb 9.

Abstract

Background and purpose: The aim of this study was to prospectively define and measure evacuation and continence disorders after preoperative radiochemotherapy and total mesorectal excision (TME) for rectal cancer 1 year after surgery.

Materials and methods: We submitted 100 patients, who underwent neoadjuvant treatment and anterior resection with TME from 1996 to 2003, to a questionnaire on postoperative continence and evacuation. Anal sphincter function was further assessed by the Memorial Sloan-Kettering score. Factors influencing anorectal function were examined in univariate and multivariate analysis.

Results: Median evacuation score was 16.12 +/- 5.12 (range 0-28). Sensation of incomplete evacuation was reported in 58% of cases, necessity to return to the bathroom <15 min in 37% and inability to evacuate completely <15 min in 35%. Median continence score was 13.7 +/- 4.79 (range 0-20). Incontinence to flatus was reported in 46% of cases. Colonic J-pouch allows better evacuation and continence. Continence was also better in absence of postoperative complications. Sphincter function resulted excellent or good in 75% of patients according to the Memorial Sloan-Kettering score.

Conclusions: The most frequent symptoms in our series are the sensation of incomplete evacuation, the incontinence to flatus, and the necessity to return to the bathroom <15 min. Colonic J-pouch warrants a better function. Postoperative complications compromise good functional results.

MeSH terms

  • Aged
  • Anal Canal / physiopathology*
  • Anastomosis, Surgical / adverse effects
  • Chemotherapy, Adjuvant
  • Colonic Pouches / adverse effects*
  • Defecation*
  • Digestive System Surgical Procedures / adverse effects*
  • Fecal Incontinence / etiology*
  • Fecal Incontinence / physiopathology
  • Flatulence / etiology*
  • Flatulence / physiopathology
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Neoadjuvant Therapy / adverse effects
  • Patient Satisfaction
  • Prospective Studies
  • Radiotherapy, Adjuvant / adverse effects
  • Recovery of Function
  • Rectal Neoplasms / drug therapy
  • Rectal Neoplasms / physiopathology
  • Rectal Neoplasms / radiotherapy
  • Rectal Neoplasms / surgery
  • Rectal Neoplasms / therapy*
  • Surveys and Questionnaires
  • Time Factors
  • Treatment Outcome