Objective: To investigate the risk factors associated with secondary drug resistance for Tuberculosis (SDR-TB).
Methods: A total of 1489 patients with TB were recruited in this study, among which 875 sought medical attentions from the institute of TB control and prevention of Sichuan province; 614 sought medical attentions from the institute of TB control and prevention of Anhui province; 356 of the patients were identified as SDR-TB. Questionnaire surveys and Logistic Regression Analysis were undertaken to investigate the social behavioral risk factors associated with SDR-TB.
Results: The length of suffering, incomplete directly observed treatment (DOTS), poor patient compliance, unsatisfied supply of medicines, floating population, interruption of treatment, and alcohol drinking were identified as major social behavioral risk factors of SDR-TB. The Odds Ratios (OR) and Confidence Intervals (CI) for the above factors were 0.279 (6.842-17.663), 9.880 (6.743-16.672), 4.683 (2.335-10.523), 3.859 (1.584-9.218), 5.030 (1.683-9.891), 4.938 (2.162-9.982) and 2.338 (1.284-7.116) respectively.
Conclusion: The results of this study has implications for improving the prevention and control of TB, in particular, for the SDR-TB.