Abstract
Prothrombotic coagulation abnormalities were analyzed in patients with untreated multiple myeloma. Increases in factor VIII, in von Willebrand factor (vWF) and a decrease in protein S were observed and these changes were strongly associated with disease stage. No difference in baseline coagulation parameters was found between patients with and without subsequent venous thromboembolism.
MeSH terms
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Aged
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Antibodies, Antiphospholipid / chemistry
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Blood Coagulation Disorders / complications*
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Blood Coagulation Disorders / diagnosis*
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Blood Coagulation*
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Case-Control Studies
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Factor VIII / biosynthesis
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Female
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Humans
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Male
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Middle Aged
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Multiple Myeloma / blood*
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Multiple Myeloma / diagnosis*
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Protein S / biosynthesis
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Venous Thrombosis / complications*
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Venous Thrombosis / diagnosis*
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von Willebrand Factor / biosynthesis
Substances
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Antibodies, Antiphospholipid
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Protein S
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von Willebrand Factor
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Factor VIII