Abstract
Most soluble protein antigens are poor at priming class I-restricted cytotoxic cell activity. In this study we show that incorporation of one protein, ovalbumin, into liposomes converts this antigen into an effective stimulator of antigen-specific cytotoxicity. The mechanisms responsible for this phenomenon are discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Drug Carriers
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Histocompatibility Antigens Class I / immunology*
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Liposomes / administration & dosage
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Mice
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Ovalbumin / administration & dosage*
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Ovalbumin / immunology
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Peptide Fragments / immunology
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Drug Carriers
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Histocompatibility Antigens Class I
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Liposomes
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Peptide Fragments
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Ovalbumin