Diabetes mellitus and heart failure: epidemiology, mechanisms, and pharmacotherapy

Frederick A Masoudi; Silvio E Inzucchi

doi:10.1016/j.amjcard.2006.11.013

Diabetes mellitus and heart failure: epidemiology, mechanisms, and pharmacotherapy

Am J Cardiol. 2007 Feb 19;99(4A):113B-132B. doi: 10.1016/j.amjcard.2006.11.013. Epub 2006 Dec 22.

Authors

Frederick A Masoudi¹, Silvio E Inzucchi

Affiliation

¹ Division of Cardiology, Department of Medicine, Denver Health Medical Center, Denver, Colorado 80204, USA. [email protected]

PMID: 17307064
DOI: 10.1016/j.amjcard.2006.11.013

Abstract

Diabetes mellitus and heart failure (HF), both of which are associated with high rates of adverse cardiovascular outcomes, commonly coexist. Given the marked increases in diabetes prevalence in developed countries, the proportion of the population with both conditions is likely to increase substantially. This article reviews the epidemiology of HF and diabetes, the mechanisms whereby diabetes causes HF, and the pharmacotherapy of both HF and diabetes. Specific challenges in treating patients with both HF and diabetes are also addressed.

Publication types

Review

MeSH terms

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Diabetes Mellitus / drug therapy*
Diabetes Mellitus / epidemiology
Diabetes Mellitus / metabolism
Fatty Acids, Nonesterified / metabolism
Heart Failure / drug therapy*
Heart Failure / epidemiology
Heart Failure / metabolism
Humans
Hyperglycemia / metabolism
Hypoglycemic Agents / therapeutic use
Insulin Resistance / physiology
Mineralocorticoid Receptor Antagonists / therapeutic use

Substances

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Fatty Acids, Nonesterified
Hypoglycemic Agents
Mineralocorticoid Receptor Antagonists