This study examined differences in associations between weight concern and smoking initiation among culturally diverse adolescents. Statistical analyses were conducted on responses from 3,515 students in the 8th and 9th grades from three school districts in Los Angeles County. The restrained eating scale, adapted from the Dutch Eating Behavior Questionnaire, was used to measure students' weight concerns. Our results indicated that weight concern was significantly associated with increased risk for smoking. Those who scored higher on weight concern were approximately 40% more likely to report having tried smoking and smoked in the past 30 days. Compared to White students who reported weight concerns, Asian-American and African-American students were significantly less likely to report having tried smoking whereas Hispanic students were more likely to report having tried smoking. Health educators may wish to design smoking prevention programs which advocate for alternative methods of weight reduction rather than using smoking as a means of weight control.