Abstract
Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Chromosomal Proteins, Non-Histone / genetics*
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Chromosomal Proteins, Non-Histone / metabolism
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Drosophila Proteins / genetics*
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Drosophila Proteins / metabolism
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Epigenesis, Genetic / genetics*
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Evolution, Molecular
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Gene Expression Regulation, Developmental / genetics*
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Histones / genetics
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Histones / metabolism
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Humans
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Polycomb-Group Proteins
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RNA Interference / physiology*
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RNA, Untranslated / genetics
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RNA, Untranslated / metabolism
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Repressor Proteins / genetics*
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Repressor Proteins / metabolism
Substances
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Chromosomal Proteins, Non-Histone
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Drosophila Proteins
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Histones
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Polycomb-Group Proteins
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RNA, Untranslated
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Repressor Proteins
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trx protein, Drosophila