Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum

Nat Genet. 2007 Mar;39(3):366-72. doi: 10.1038/ng1980. Epub 2007 Feb 18.

Abstract

Autosomal recessive hereditary spastic paraplegia (ARHSP) with thin corpus callosum (TCC) is a common and clinically distinct form of familial spastic paraplegia that is linked to the SPG11 locus on chromosome 15 in most affected families. We analyzed 12 ARHSP-TCC families, refined the SPG11 candidate interval and identified ten mutations in a previously unidentified gene expressed ubiquitously in the nervous system but most prominently in the cerebellum, cerebral cortex, hippocampus and pineal gland. The mutations were either nonsense or insertions and deletions leading to a frameshift, suggesting a loss-of-function mechanism. The identification of the function of the gene will provide insight into the mechanisms leading to the degeneration of the corticospinal tract and other brain structures in this frequent form of ARHSP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Animals
  • Base Sequence
  • COS Cells
  • Cerebral Cortex / metabolism
  • Child
  • Chlorocebus aethiops
  • Chromosomes, Human, Pair 15
  • Corpus Callosum / pathology*
  • DNA Mutational Analysis
  • Genetic Linkage
  • Genotype
  • Humans
  • Lod Score
  • Molecular Sequence Data
  • Mutation*
  • Pedigree
  • Proteins / genetics*
  • Proteins / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Spastic Paraplegia, Hereditary / genetics*
  • Spastic Paraplegia, Hereditary / pathology*

Substances

  • Proteins
  • SPG11 protein, human

Associated data

  • GENBANK/BAE27954
  • RefSeq/NM_025137
  • RefSeq/XP_242139
  • RefSeq/XP_413940
  • RefSeq/XP_544657