Abstract
A bioassay-guided fractionation of the EtOH extract of the Madagascan plant Terminalia calcicola led to the isolation of two new cytotoxic xanthones, termicalcicolanone A (1) and termicalcicolanone B (2). The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic data. Both compounds showed modest antiproliferative activity toward the A2780 human ovarian cancer cell line.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Female
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Humans
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Madagascar
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Terminalia / chemistry*
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Xanthones* / chemistry
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Xanthones* / isolation & purification
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Xanthones* / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Xanthones
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termicalcicolanone A
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termicalcicolanone B