Objective: To analyze the incidence, risk factors, treatment and prognosis of early stage infection after auto peripheral blood stem cell transplantation (APBSCT).
Methods: The clinical data of 120 patients receiving APBSCT were analyzed.
Results: The incidence rate of infection was 57.5% (69/120), with most of them (68/69) bacterial in origin. 2.5% (3/120) the patients died of infection. The first infection was usually observed on the 6th day after APBSCT and lasted for a median of 2 (1 - 23) days. Positive blood culture was found in 16.0% (11/69) of the patients, with all of them G(-) bacteria. Patients with age more than 45 years and not receiving CD(34)(+) sorting had higher infection rate. 61.8% (42/68) of the patients responded to treatment for the first infection within 48 hours.
Conclusions: The early stage infection rate after APBSCT is 57.5%, with most of them bacterial in origin. Most of the infections respond to broad-spectrum antibiotics. Patients with age more than 45 years and not receiving CD(34)(+) sorting have higher infection rate.