Abstract
This open-label prospective study evaluated the efficacy of letrozole (2.5 mg/day) combined with norethisterone acetate (2.5 mg/day) in the treatment of pain symptoms related to the presence of rectovaginal endometriosis. The treatment significantly and quickly decreased the intensity of symptoms, but pain recurred at 3-month follow-up; five women underwent surgery during the follow-up, and histologic examination of rectovaginal nodules revealed the presence of active endometriotic lesions.
MeSH terms
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Administration, Oral
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Aromatase Inhibitors / administration & dosage
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Aromatase Inhibitors / therapeutic use*
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Contraceptives, Oral, Synthetic / administration & dosage
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Contraceptives, Oral, Synthetic / therapeutic use*
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Drug Therapy, Combination
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Female
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Humans
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Letrozole
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Nitriles / administration & dosage
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Nitriles / therapeutic use*
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Norethindrone / analogs & derivatives
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Norethindrone Acetate
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Prospective Studies
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Rectal Diseases / drug therapy*
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Triazoles / administration & dosage
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Triazoles / therapeutic use*
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Vaginal Diseases / drug therapy*
Substances
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Aromatase Inhibitors
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Contraceptives, Oral, Synthetic
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Nitriles
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Triazoles
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Letrozole
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Norethindrone Acetate
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Norethindrone