Abstract
Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / isolation & purification*
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Chromatography, High Pressure Liquid
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Escherichia coli / growth & development
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Escherichia coli / metabolism*
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Molecular Conformation
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Spectrometry, Mass, Electrospray Ionization
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Tandem Mass Spectrometry
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Thiamine Triphosphate / isolation & purification*
Substances
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adenosine thiamine triphosphate
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Thiamine Triphosphate
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Adenosine Triphosphate
Associated data
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PubChem-Substance/22387977
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PubChem-Substance/22387978
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PubChem-Substance/22387979
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PubChem-Substance/22387980
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PubChem-Substance/22387981
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PubChem-Substance/22387982
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PubChem-Substance/22387983
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PubChem-Substance/22387984
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PubChem-Substance/22387985
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PubChem-Substance/22387986
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PubChem-Substance/22387987
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PubChem-Substance/22387988
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PubChem-Substance/22387989
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PubChem-Substance/22387990
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PubChem-Substance/22387991