Semantic priming modulates the N400, N300, and N400RP

Clin Neurophysiol. 2007 May;118(5):1053-68. doi: 10.1016/j.clinph.2007.01.012. Epub 2007 Mar 1.

Abstract

Objective: To determine whether ERP components can differentiate between the semantic priming mechanisms of automatic spreading activation, expectancy, and semantic matching.

Methods: The present study manipulated two factors known to differentiate semantic priming mechanisms: associations between words (forward, backward, and symmetrical) and prime-target stimulus onset asynchrony (SOA). Twenty-six participants were tested in each SOA condition while high-density 128-channel data were collected. Principal components analysis was applied to separate the ERP components.

Results: Priming was observed for all conditions. Three semantic components were present: (1) the standard N400 effect for symmetric and forward priming pairs at both short and long SOAs, (2) an N300 for the long SOA symmetric priming pairs, and (3) a right-lateralized posterior N400RP for long SOA backward priming pairs.

Conclusions: Results suggest that the N300 reflects expectancy, but only for categorical and/or semantic similarity priming. Results further suggest that the N400RP is a replicable ERP component that responds to semantic matching. There is also some evidence that the N400 indirectly responds to both ASA and expectancy, perhaps as part of a post-lexical updating process and that backward priming at short SOAs is different from that at long SOAs.

Significance: Improved understanding of the semantic properties of the N400 and related ERP components may increase their utility for understanding language processes and for diagnostic purposes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cognition / physiology
  • Cortical Synchronization
  • Cues*
  • Data Interpretation, Statistical
  • Electroencephalography
  • Evoked Potentials / physiology*
  • Female
  • Frontal Lobe / physiology
  • Functional Laterality / physiology
  • Humans
  • Male
  • Principal Component Analysis
  • Psychomotor Performance / physiology
  • Reaction Time / physiology