Abstract
Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the destruction of tumour cells. If boronated agents are targeted towards chromosomal DNA, the efficiency of BNCT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Alkylating Agents / chemistry
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Alkylating Agents / therapeutic use
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Animals
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Boron Compounds / chemistry*
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Boron Compounds / therapeutic use
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Boron Neutron Capture Therapy*
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DNA / chemistry*
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Humans
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Intercalating Agents / chemistry
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Intercalating Agents / therapeutic use
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Molecular Structure
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Neoplasms / radiotherapy*
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Nucleosides / chemistry
Substances
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Alkylating Agents
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Boron Compounds
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Intercalating Agents
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Nucleosides
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DNA