Abstract
The fungus Daedalea quercina (oak mazegill) was examined for its capability of producing antioxidative and anti-inflammatory compounds. Bioactivity guided fractionation of the extract from a mycelial culture led to the isolation of quercinol, which was identified as (-)-(2S)-2-hydroxymethyl-2-methyl-6-hydroxychromene 1 by NMR and X-ray analyses. The cryptic hydroquinone 1 shows a broad anti-inflammatory activity against cyclooxygenase 2 (COX-2), xanthine oxidase (XO), and horseradish peroxidase (HRP) at micromolar concentrations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / pharmacology*
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Basidiomycota / metabolism*
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Benzopyrans / chemical synthesis
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Benzopyrans / chemistry*
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Benzopyrans / pharmacology
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Chemistry, Pharmaceutical / methods*
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Crystallography, X-Ray
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Cyclooxygenase 2 / chemistry
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Cyclooxygenase Inhibitors / pharmacology
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Drug Design
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Horseradish Peroxidase / antagonists & inhibitors
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Magnetic Resonance Spectroscopy
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Models, Chemical
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Molecular Conformation
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Xanthine Oxidase / antagonists & inhibitors
Substances
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Anti-Inflammatory Agents
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Benzopyrans
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Cyclooxygenase Inhibitors
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quercinol
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Horseradish Peroxidase
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Cyclooxygenase 2
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Xanthine Oxidase