Abstract
An amphiphilic macrocyclic cavitand that shows good antibacterial activity, comparable to that of peptide-based antibiotics was developed by rational design and its antibacterial selectivity over mammalian cells was examined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Bridged-Ring Compounds / chemical synthesis*
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Bridged-Ring Compounds / chemistry
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Bridged-Ring Compounds / pharmacology
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Cell Survival / drug effects
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Imidazoles / chemistry
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Macrocyclic Compounds / chemical synthesis*
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Macrocyclic Compounds / chemistry
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Macrocyclic Compounds / pharmacology
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Mice
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Microbial Sensitivity Tests
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NIH 3T3 Cells
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Unilamellar Liposomes / metabolism
Substances
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Anti-Bacterial Agents
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Bridged-Ring Compounds
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Imidazoles
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Macrocyclic Compounds
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Unilamellar Liposomes
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cucurbit(6)uril