Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM

Yen Kuang Yang; Wei Jen Yao; Tzung Lieh Yeh; I Hui Lee; Kao Ching Chen; Ru Band Lu

doi:10.1016/j.pscychresns.2006.11.010

Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM

Psychiatry Res. 2007 Apr 15;154(3):281-4. doi: 10.1016/j.pscychresns.2006.11.010. Epub 2007 Mar 8.

Authors

Yen Kuang Yang¹, Wei Jen Yao, Tzung Lieh Yeh, I Hui Lee, Kao Ching Chen, Ru Band Lu

Affiliation

¹ Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, Taiwan. [email protected]

PMID: 17349781
DOI: 10.1016/j.pscychresns.2006.11.010

Abstract

The present study examined the relationship between serotonin transporter (SERT) availability and hostility scores in healthy volunteers. SERT availability was measured by using SPECT with [(123)I] ADAM in 10 healthy participants. Hostility was measured with the Cook-Medley Hostility Scale. Hostile attribution, but not the other subscales of hostility, was negatively correlated with SERT availability. Central serotoninergic activities may play a role in hostility.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain / metabolism*
Cinanserin / administration & dosage
Cinanserin / analogs & derivatives*
Cinanserin / pharmacokinetics
Female
Hostility*
Humans
Injections, Intravenous
Iodine Radioisotopes* / administration & dosage
Iodine Radioisotopes* / pharmacokinetics
Male
Serotonin Plasma Membrane Transport Proteins / metabolism*
Tomography, Emission-Computed, Single-Photon*

Substances

2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine
Iodine Radioisotopes
Serotonin Plasma Membrane Transport Proteins
Cinanserin