Abstract
The design, synthesis, and SAR of a series of substituted spirohydantoins are described. Optimization of an in-house screening hit gave compounds that exhibited potent binding affinity and functional activity at MCH-R1.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Obesity Agents / chemical synthesis*
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Anti-Obesity Agents / pharmacology
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Drug Design
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Humans
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Hydantoins / chemical synthesis*
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Hydantoins / pharmacology
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Kinetics
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Protein Binding
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Receptors, Pituitary Hormone / antagonists & inhibitors*
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / pharmacology
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Structure-Activity Relationship
Substances
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Anti-Obesity Agents
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Hydantoins
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Receptors, Pituitary Hormone
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Spiro Compounds
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melanin-concentrating hormone receptor