Abstract
To evaluate the effect of fosfomycin on proinflammatory cytokines, a bolus of 2 ng of bacterial lipopolysaccharide/kg of body weight was injected intravenously into healthy volunteers. After 2 h, subjects received 8 g of fosfomycin or placebo in a randomized crossover study design. The resulting concentrations of tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-6 expressed as protein and mRNA levels were almost identical with and without fosfomycin.
Publication types
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Adult
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Anti-Bacterial Agents / pharmacology*
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Cytokines / blood*
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Endotoxemia / immunology*
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Fosfomycin / pharmacology*
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Humans
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Interleukin-1beta / blood
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Interleukin-6 / blood
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Lipopolysaccharides / toxicity
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Male
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Prospective Studies
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Tumor Necrosis Factor-alpha / blood
Substances
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Anti-Bacterial Agents
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Cytokines
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Interleukin-1beta
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Interleukin-6
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Lipopolysaccharides
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Tumor Necrosis Factor-alpha
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Fosfomycin