Abstract
Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.
MeSH terms
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Animals
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / pharmacology*
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Drug Design*
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Giardia / drug effects*
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Humans
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Molecular Structure
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Nucleotides / chemistry
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Nucleotides / pharmacology*
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Organophosphonates / chemistry
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Organophosphonates / pharmacology*
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Structure-Activity Relationship
Substances
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Antiprotozoal Agents
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Nucleotides
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Organophosphonates