Abstract
Metastasis to the brain is prevalent in solid tumors and lymphomas, and is associated with shortened survival. The brain is regarded as a sanctuary site for metastatic tumor cells where they exist partially protected from drugs by the blood-tumor barrier. Model systems for brain metastasis have been developed and are now yielding mechanistic insights into the roles of angiogenesis, energy metabolism, the Her-2 and Stat3 signaling pathways, and dormancy. Specific, new approaches to combat brain metastatic disease are needed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Brain / blood supply
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Brain Neoplasms / blood supply
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Brain Neoplasms / etiology*
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Brain Neoplasms / secondary*
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Cell Membrane Permeability / physiology
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Disease Models, Animal
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Disease Progression
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Energy Metabolism / physiology
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Humans
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Melanoma, Experimental / pathology
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Models, Biological
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Neovascularization, Pathologic / pathology
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Receptor, ErbB-2 / physiology
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STAT3 Transcription Factor / physiology
Substances
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STAT3 Transcription Factor
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Receptor, ErbB-2