Abstract
We present the clinical, radiological and pathological features of a case of a cranial hypertrophic pachymeningitis that developed in the course of mastoiditis and petrous apex inflammation and responded to immunosuppressive therapy only. Documented by the development of clinical findings, magnetic resonance imaging, cerebrospinal fluid changes, histopathology findings, by otosurgical intervention and finally by the insertion of a ventriculo-peritoneal shunt, the case illustrates a gradual development of pachymeningitis with consequent hydrocephalus and intracranial hypertension. We consider this disease development an example of immune-induced proliferative fibrotic changes in meninges.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Abducens Nerve Diseases / complications*
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Anti-Bacterial Agents / therapeutic use
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Ceftriaxone / therapeutic use
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Cerebrospinal Fluid / immunology
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Chloramphenicol / therapeutic use*
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Drug Therapy, Combination
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Humans
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Hydrocephalus / complications*
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Hydrocephalus / pathology*
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Hypertrophy / pathology
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Immunoglobulin G / cerebrospinal fluid
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Immunosuppressive Agents / therapeutic use
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Magnetic Resonance Imaging
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Male
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Mastoiditis / complications*
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Mastoiditis / drug therapy
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Mastoiditis / pathology
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Meninges / pathology
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Meningitis / complications*
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Meningitis / drug therapy*
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Meningitis / pathology
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Methotrexate / therapeutic use
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Methylprednisolone / therapeutic use
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Middle Aged
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Otitis Media / complications*
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Otitis Media / surgery
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Petrous Bone / pathology*
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Syndrome
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Trigeminal Nerve Diseases / complications*
Substances
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Anti-Bacterial Agents
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Immunoglobulin G
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Immunosuppressive Agents
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Chloramphenicol
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Ceftriaxone
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Methylprednisolone
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Methotrexate