Expression of chicken interleukin-2 by turkey herpesvirus increases the immune response against Marek's disease virus but fails to increase protection against virulent challenge

Avian Pathol. 2007 Feb;36(1):69-74. doi: 10.1080/03079450601113159.

Abstract

As Marek's disease virus continues to evolve towards greater virulence, more efficacious vaccines will be required in the future. We expressed chicken interleukin-2 (IL-2) from a turkey herpesvirus (HVT) in an attempt to increase the efficacy of HVT as a vaccine against Marek's disease. The recombinant IL-2/HVT was safe for in ovo vaccination, although it replicated less in the birds compared with the parent HVT strain. Expression of IL-2 increased the neutralizing antibody response against HVT but did not increase the protection against virulent Marek's disease virus challenge.

Publication types

  • Clinical Trial

MeSH terms

  • Animals
  • Antibodies, Viral / blood
  • Chick Embryo
  • Chickens / genetics*
  • Gene Expression*
  • Herpesvirus 1, Meleagrid / genetics*
  • Interleukin-2 / genetics
  • Interleukin-2 / immunology
  • Interleukin-2 / metabolism*
  • Mardivirus / immunology
  • Mardivirus / pathogenicity*
  • Marek Disease / immunology*
  • Marek Disease / prevention & control
  • Marek Disease / virology
  • Poultry Diseases / immunology
  • Poultry Diseases / prevention & control
  • Poultry Diseases / virology
  • Viral Vaccines / adverse effects
  • Viral Vaccines / immunology*
  • Virulence
  • Weight Gain

Substances

  • Antibodies, Viral
  • Interleukin-2
  • Viral Vaccines