Abstract
Environmental fungi, in particular primary pathogens and Cryptococcus spp. can be responsible for skin lesions mimicking sporotrichosis. In this paper, we report a case of subcutaneous cryptococcosis in an apparently healthy, young male patient due to a non-C. neoformans Cryptococcus species, C. diffluens. The isolate showed in vitro phenotypic switching that may affect virulence and host inflammatory and immune responses, and in vitro resistance to amphotericin B and 5-flucytosin. This species shares several phenotypic traits with C. neoformans, and, therefore, decisive diagnosis should be based on biopsy and culturing results followed by molecular identification.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Amphotericin B / pharmacology
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Antifungal Agents / pharmacology
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Base Sequence
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Cryptococcosis / diagnosis
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Cryptococcosis / microbiology*
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Cryptococcosis / pathology
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Cryptococcus / cytology
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Cryptococcus / drug effects*
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Cryptococcus / isolation & purification*
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Cryptococcus / physiology
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DNA, Fungal / chemistry
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DNA, Fungal / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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DNA, Ribosomal Spacer / chemistry
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DNA, Ribosomal Spacer / genetics
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Diagnosis, Differential
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Drug Resistance, Fungal
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Flucytosine / pharmacology
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Humans
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Male
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Microbial Sensitivity Tests
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Molecular Sequence Data
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RNA, Ribosomal, 28S / genetics
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Sequence Analysis, DNA
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Sporotrichosis / diagnosis
Substances
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Antifungal Agents
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DNA, Fungal
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DNA, Ribosomal
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DNA, Ribosomal Spacer
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RNA, Ribosomal, 28S
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Amphotericin B
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Flucytosine
Associated data
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GENBANK/DQ242643
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GENBANK/DQ242644