The objective of the present study was to determine effects of strain of Holstein-Friesian and feed system on body weight (BW) and body condition score (BCS; scale of 1 to 5) lactation profiles in seasonal-calving, grass-based milk production systems. The 3 strains of Holstein-Friesian compared differed in milk production potential and were high-production North American (HP), high-durability North American (HD), and New Zealand (NZ). The 3 feed systems compared were a high grass allowance feed system typical of spring-calving herds in Ireland (MP); an increased stocking rate system (HS); and an increased concentrate supplementation system (HC), each maintained within a separate farmlet. The data comprised 20,611 weekly BW and 7,920 BCS records assessed every 3 wk across 5 yr on 584 lactations. An exponential function was used to model BW and BCS lactation profiles across feed systems. Across feed systems, the NZ strain was significantly lighter (545 kg) but had greater average BCS (3.10 units) compared with the HP (579.3 kg and 2.76 units, respectively) and HD strains (583.2 kg and 2.87 units, respectively). Across feeding systems, the HD and HP strains exhibited a greater loss of BCS in early lactation (0.27 and 0.29 units, respectively) compared with the NZ strain (0.21 units). The HP strain failed to gain BCS over the entire lactation. Concentrate input did not affect the rate of BCS or BW loss in early lactation or BCS at 60 DIM. This study extends previous research outlining the greater suitability of the NZ strain to the low-cost grass-based system of milk production predominantly operated in Ireland.