Specificity of glutamate receptors in P2 synaptosomal fraction from rat brain cortex

Bull Exp Biol Med. 2006 Jul;142(1):43-6. doi: 10.1007/s10517-006-0287-9.
[Article in English, Russian]

Abstract

Specificity of glutamate receptors in the P2 synaptosomal fraction from the cerebral cortex of newborn rats was studied by measuring (45)Ca(2+) uptake by synaptosomes in the presence of agonists of ionotropic and metabotropic glutamate receptors. It was shown that P2 synaptosomal fraction from rat cortex contains NMDA receptors, kainate receptors, and group 1 metabotropic receptors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism
  • Cerebral Cortex / metabolism*
  • Excitatory Amino Acid Agonists / metabolism
  • Rats
  • Rats, Wistar
  • Receptors, Glutamate / metabolism*
  • Receptors, Kainic Acid / metabolism
  • Receptors, Metabotropic Glutamate / metabolism
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Synaptosomes / metabolism*

Substances

  • Excitatory Amino Acid Agonists
  • Receptors, Glutamate
  • Receptors, Kainic Acid
  • Receptors, Metabotropic Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • Calcium