Abstract
Hormone replacement therapy (HRT) containing estrogens is generally used to relieve climacteric symptoms and to prevent osteoporosis and coronary heart disease [1], however, there has been increasing evidence of the HRT as the risk of hormone-dependent neoplasms including breast cancer [2], uterine endometrial cancer [3], ovarian cancer [4], and even lung cancer [5]. Noteworthy is mucinous cyst neoplasms (MCNs) of the pancreas, characterized by mucin-producing columnar epithelium supported by "ovarian-like" mesenchymal stroma, occur mostly in females expressing estrogen receptors [6, 7]. Although several reports regarding the closed relationship between MCNs and pregnancy [8, 9] might imply potential sex hormone-dependency of the MCNs [10], no correlation has been reported. This is the first case report of malignant MCN developing during continuous HRT after hysterectomy.
MeSH terms
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Cystadenocarcinoma, Mucinous / chemically induced*
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Cystadenocarcinoma, Mucinous / chemistry
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Cystadenocarcinoma, Mucinous / pathology
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Cystadenocarcinoma, Mucinous / surgery
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Estrogen Replacement Therapy / adverse effects*
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Female
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Humans
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Hysterectomy
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Inhibins / analysis
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Middle Aged
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Neoplasms, Hormone-Dependent / chemically induced*
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Neoplasms, Hormone-Dependent / chemistry
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Neoplasms, Hormone-Dependent / pathology
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Neoplasms, Hormone-Dependent / surgery
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Pancreatectomy
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Pancreatic Neoplasms / chemically induced*
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Pancreatic Neoplasms / chemistry
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Pancreatic Neoplasms / pathology
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Pancreatic Neoplasms / surgery
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Receptors, Estrogen / analysis
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Receptors, Progesterone / analysis
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Splenectomy
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Stromal Cells / chemistry
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Stromal Cells / drug effects*
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Stromal Cells / pathology
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Treatment Outcome
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Ultrasonography / methods
Substances
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Receptors, Estrogen
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Receptors, Progesterone
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Inhibins