COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G>C with disease risk

S Mazzola; M Gomez Lira; M D Benedetti; A Salviati; S Ottaviani; G Malerba; M Ortombina; P F Pignatti

doi:10.1111/j.1744-313X.2007.00675.x

COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G>C with disease risk

Int J Immunogenet. 2007 Apr;34(2):71-4. doi: 10.1111/j.1744-313X.2007.00675.x.

Authors

S Mazzola¹, M Gomez Lira, M D Benedetti, A Salviati, S Ottaviani, G Malerba, M Ortombina, P F Pignatti

Affiliation

¹ Department of Mother and Child, Biology and Genetics, Section Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. [email protected]

PMID: 17373929
DOI: 10.1111/j.1744-313X.2007.00675.x

Abstract

Cyclooxygenase-2 (COX-2) is extensively expressed in multiple sclerosis lesions suggesting that regulatory variants of the COX-2 gene could be implicated in multiple sclerosis (MS). Screening of the proximal 5' regulatory region and genotyping of -765G>C and -62C>G showed that polymorphisms in this COX-2 region are unlikely to be involved in MS susceptibility.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclooxygenase 2 / genetics*
Female
Genetic Predisposition to Disease
Humans
Male
Membrane Proteins / genetics*
Multiple Sclerosis / enzymology
Multiple Sclerosis / genetics*
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics
Risk

Substances

Membrane Proteins
Cyclooxygenase 2
PTGS2 protein, human