Abstract
Six new minor dammarane triterpenoids were isolated from the roots of Gentiana rigescens. These include one aglycone, gentirigenic acid (1), and five glycosides, gentirigeosides A-E (2-6). Their structures were elucidated through detailed spectroscopic analyses, including 1D and 2D NMR techniques, and enzymatic hydrolysis. Antifungal testing of these compounds showed that the glycosides gentirigeosides A (2), C (4), and E (6) had antifungal activity against the plant pathogen Glomerella cingulata.
MeSH terms
-
Antifungal Agents / chemistry
-
Antifungal Agents / isolation & purification*
-
Antifungal Agents / pharmacology
-
Dammaranes
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Gentiana / chemistry*
-
Glycosides / chemistry
-
Glycosides / isolation & purification
-
Glycosides / pharmacology
-
Molecular Structure
-
Phyllachorales / drug effects*
-
Plant Roots / chemistry
-
Plants, Medicinal / chemistry*
-
Triterpenes / chemistry
-
Triterpenes / isolation & purification*
-
Triterpenes / pharmacology
Substances
-
Antifungal Agents
-
Drugs, Chinese Herbal
-
Glycosides
-
Triterpenes