Hyrtinadine A, a bis-indole alkaloid from a marine sponge

Taeko Endo; Masashi Tsuda; Jane Fromont; Jun'ichi Kobayashi

doi:10.1021/np060420n

Hyrtinadine A, a bis-indole alkaloid from a marine sponge

J Nat Prod. 2007 Mar;70(3):423-4. doi: 10.1021/np060420n.

Authors

Taeko Endo¹, Masashi Tsuda, Jane Fromont, Jun'ichi Kobayashi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 17378531
DOI: 10.1021/np060420n

Abstract

A new cytotoxic bis-indole alkaloid, hyrtinadine A (1), with a pyrimidine moiety has been isolated from an Okinawan marine sponge Hyrtios sp., and the structure was elucidated on the basis of spectroscopic data.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology
Inhibitory Concentration 50
KB Cells
Marine Biology
Molecular Structure
Porifera / chemistry*

Substances

Antineoplastic Agents
Indole Alkaloids
hyrtinadine A