Standardization of (67)Ga using a 4pi(LS)beta-gamma anti-coincidence system

Appl Radiat Isot. 2007 Jul;65(7):757-63. doi: 10.1016/j.apradiso.2007.01.003. Epub 2007 Feb 6.

Abstract

(67)Ga is an interesting radionuclide as it is widely used in nuclear medicine. The meta-stable level related to the 93.3keV gamma-transition represents the main difficulty when using the coincidence method to standardize this radionuclide. The 4pi(LS)beta-gamma anti-coincidence system implemented at LNHB is based on the use of electronic modules specifically designed for radioactivity metrology. On the contrary to classical coincidence systems, activity measurements of (67)Ga are carried out as for prompt beta-gamma emitters; indeed, when using a live-timed anti-coincidence system with extendable dead times, the problem due to the excess of counting generated by the meta-stable level is avoided. Considering that the standardization of (67)Ga does not depend on the decay scheme parameters (except for the half-life), the measurement of the gamma-emission intensities has been performed. The standardization of this radionuclide was also a good opportunity for a new participation of our laboratory in the SIR of (67)Ga (International Reference System); the result obtained with the 4pi(LS)beta-gamma anti-coincidence system is compared with those submitted by other National Metrology Institutes (NMIs). The non-extendable dead times used in most of the participations could be one of the causes responsible for the abnormal dispersion of the results. The optimization of the standard solution of (67)Ga for the radioactive source preparation is also discussed.

MeSH terms

  • Beta Particles / therapeutic use
  • Gallium Radioisotopes / chemistry*
  • Gallium Radioisotopes / standards
  • Gamma Rays / therapeutic use
  • Radiometry
  • Reference Standards

Substances

  • Gallium Radioisotopes