Abstract
The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT (213)Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET.
MeSH terms
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Alpha Particles
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Antimetabolites, Antineoplastic / pharmacology
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Cell Cycle / drug effects
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Cell Cycle / radiation effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Proliferation / radiation effects
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Deoxycytidine / analogs & derivatives*
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Deoxycytidine / pharmacology
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Gamma Rays
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Gemcitabine
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Humans
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Linear Energy Transfer*
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Multiple Myeloma / pathology
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Multiple Myeloma / radiotherapy*
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Radiation Dosage
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Radiation Tolerance / drug effects*
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Radiation-Sensitizing Agents / pharmacology*
Substances
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Antimetabolites, Antineoplastic
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Radiation-Sensitizing Agents
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Deoxycytidine
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Gemcitabine