On again, off again: the SRC-3 transcriptional coactivator moonlights as a translational corepressor

Paul Anderson; Nancy Kedersha

doi:10.1016/j.molcel.2007.03.005

On again, off again: the SRC-3 transcriptional coactivator moonlights as a translational corepressor

Mol Cell. 2007 Mar 23;25(6):796-7. doi: 10.1016/j.molcel.2007.03.005.

Authors

Paul Anderson¹, Nancy Kedersha

Affiliation

¹ Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA.

PMID: 17386257
DOI: 10.1016/j.molcel.2007.03.005

Abstract

In a recent issue of Molecular Cell, Yu et al. (2007) reported that the steroid receptor coactivator-3 (SRC-3) has a novel cytoplasmic function: it activates the translational silencers TIA-1 and TIAR and thus inhibits the translation of proinflammatory cytokines.

Publication types

Comment

MeSH terms

Animals
Cell Nucleus / physiology
Histone Acetyltransferases / metabolism*
Humans
Nuclear Receptor Coactivator 3
Protein Biosynthesis*
RNA, Messenger / genetics
Trans-Activators / metabolism*
Transcription, Genetic*
Tumor Necrosis Factor-alpha / genetics

Substances

RNA, Messenger
Trans-Activators
Tumor Necrosis Factor-alpha
Histone Acetyltransferases
NCOA3 protein, human
Nuclear Receptor Coactivator 3

Grants and funding

R56 AI033600/AI/NIAID NIH HHS/United States