Abstract
Identification of factors associated with risk of relapse after treatment for high-grade cervical intraepithelial neoplasia (CIN) has important clinical implications. Study subjects were women participating in the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study who were treated for CIN3 by loop electrosurgical excision procedure (LEEP) and who had a baseline infection with human papillomavirus type 16 (HPV16). These women were followed every 6 months for 2 years. Post-LEEP CIN2-3 was found in 20 (10.0%) of the 201 women. An adjusted relative risk of 3.1 (95% confidence interval, 1.1-8.9) was associated with HPV16 non-European, compared with European, variants, a finding that is consistent with the variant-related risk of prevalent/incident high-grade CIN.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
MeSH terms
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Colposcopy
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Disease-Free Survival
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Electrosurgery
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Female
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Human papillomavirus 16 / genetics
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Human papillomavirus 16 / isolation & purification*
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Humans
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Neoplasm Recurrence, Local / epidemiology*
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Neoplasm Recurrence, Local / pathology
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Neoplasm Recurrence, Local / surgery
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Neoplasm Recurrence, Local / virology
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Neoplasm Staging
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Papillomavirus Infections / epidemiology*
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Papillomavirus Infections / pathology
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Papillomavirus Infections / surgery
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Papillomavirus Infections / virology
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Proportional Hazards Models
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Risk Factors
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United States / epidemiology
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Uterine Cervical Dysplasia / epidemiology*
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Uterine Cervical Dysplasia / pathology
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Uterine Cervical Dysplasia / surgery
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Uterine Cervical Dysplasia / virology
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Uterine Cervical Neoplasms / epidemiology*
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Uterine Cervical Neoplasms / pathology
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Uterine Cervical Neoplasms / surgery
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Uterine Cervical Neoplasms / virology