Abstract
A new dimeric lactone, ardimerin digallate (1), was isolated from the whole plants of Ardisia japonica, along with six known constituents. The structure of 1 was established on the basis of spectroscopic analysis including 1D- and 2D-NMR techniques. Compound 1 inhibited HIV-1 and HIV-2 RNase H in vitro with IC50 values of 1.5 and 1.1 microM, respectively.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, N.I.H., Intramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-HIV Agents / chemistry
-
Anti-HIV Agents / isolation & purification*
-
Anti-HIV Agents / pharmacology*
-
Ardisia / chemistry*
-
HIV-1 / enzymology*
-
HIV-2 / enzymology*
-
Lactones / chemistry
-
Lactones / isolation & purification*
-
Lactones / pharmacology*
-
Plants, Medicinal / chemistry*
-
Ribonuclease H / antagonists & inhibitors*
Substances
-
Anti-HIV Agents
-
Lactones
-
ardimerin digallate
-
Ribonuclease H