Abstract
The combined disk assay has been used for detection of metallo-beta-lactamase-producing isolates. We have observed that the size of inhibition zones produced by many beta-lactam/metallo-beta-lactamase inhibitor (IMBL) combinations may differ depending on the way that the combined disks were prepared. Among the 10 beta-lactam/IMBL combinations tested, only the imipenem/EDTA combination produced similar results.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Agar
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Anti-Bacterial Agents / pharmacology*
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Carbapenems / pharmacology
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Ceftazidime / pharmacology*
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Culture Media
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Gram-Negative Bacteria / drug effects*
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Gram-Negative Bacteria / enzymology
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Gram-Negative Bacteria / isolation & purification
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Humans
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Imipenem / pharmacology*
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Microbial Sensitivity Tests / instrumentation*
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Microbial Sensitivity Tests / methods
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beta-Lactam Resistance
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beta-Lactamase Inhibitors
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beta-Lactamases / biosynthesis*
Substances
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Anti-Bacterial Agents
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Carbapenems
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Culture Media
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beta-Lactamase Inhibitors
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Imipenem
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Agar
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Ceftazidime
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beta-Lactamases