Abstract
A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of 0.1 and 0.2 mg/kg, the agonist reduced anxiety, but had no effect on motor activity. It is hypothesized that low doses of MK-212 exhibited anxiolytic activity in mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anxiety / drug therapy*
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Behavior, Animal / drug effects*
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Corticosterone / blood*
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Depression, Chemical
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Male
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Mice
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Mice, Inbred CBA
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Motor Activity / drug effects*
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Pyrazines / pharmacology*
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Serotonin 5-HT2 Receptor Agonists*
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Serotonin Receptor Agonists / pharmacology
Substances
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Pyrazines
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Serotonin 5-HT2 Receptor Agonists
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Serotonin Receptor Agonists
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6-chloro-2-(1-piperazinyl)pyrazine
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Corticosterone