Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy

Trends Cardiovasc Med. 2007 Apr;17(3):91-6. doi: 10.1016/j.tcm.2007.01.004.

Abstract

A number of signaling pathways are involved in the regulation of cardiac hypertrophy and remodeling. One that serves as an integrator of upstream inputs, and as a transducer to downstream effectors, is the protein kinase, glycogen synthase kinase-3beta. In this work we review the role of this putative "nodal point" in the response of the heart to growth stimuli, both physiologic and pathologic.

Publication types

  • Review

MeSH terms

  • Animals
  • Enzyme Activation / drug effects
  • Glycogen Synthase Kinase 3 / antagonists & inhibitors
  • Glycogen Synthase Kinase 3 / metabolism*
  • Glycogen Synthase Kinase 3 beta
  • Humans
  • Hypertrophy, Left Ventricular / metabolism*
  • Hypertrophy, Left Ventricular / physiopathology
  • Hypertrophy, Left Ventricular / prevention & control*
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / pathology
  • Protein Kinase Inhibitors / pharmacology
  • Signal Transduction / drug effects
  • Ventricular Remodeling / drug effects
  • Wnt Proteins / metabolism

Substances

  • Protein Kinase Inhibitors
  • Wnt Proteins
  • GSK3B protein, human
  • Glycogen Synthase Kinase 3 beta
  • Glycogen Synthase Kinase 3