Waiting to inhale: HIF-1 modulates aerobic respiration

Adam T Boutin; Randall S Johnson

doi:10.1016/j.cell.2007.03.031

Waiting to inhale: HIF-1 modulates aerobic respiration

Cell. 2007 Apr 6;129(1):29-30. doi: 10.1016/j.cell.2007.03.031.

Authors

Adam T Boutin¹, Randall S Johnson

Affiliation

¹ Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

PMID: 17418782
DOI: 10.1016/j.cell.2007.03.031

Abstract

The hypoxia-inducible factor HIF-1 is known to promote anaerobic respiration during low oxygen conditions (hypoxia). In this issue, Fukuda et al. (2007) expand the range of HIF-1's functions by showing that it modulates aerobic respiration as well.

Publication types

Comment

MeSH terms

Aerobiosis
Animals
Cell Hypoxia
Cell Respiration*
Electron Transport Complex IV / metabolism*
Humans
Hypoxia-Inducible Factor 1 / metabolism*
Mitochondria / metabolism
Yeasts / metabolism

Substances

Hypoxia-Inducible Factor 1
Electron Transport Complex IV